rb gene การใช้

• Many tumor cells have sabotaged the Rb gene and in about 60 percent the p53 gene is also mutated.
• All cancer cells must therefore knock out their Rb protein, either directly or indirectly, by acquiring mutations in the Rb gene itself or the genes that control it.
• Onyx-015 attacks cells whose p53 protein is inactive, and another virus, Onyx-411, is designed to flourish in cells that have inactivated their Rb gene.
• In this case, should a cell sustain only " one " mutation in the other RB gene, all Rb in that cell would be ineffective at inhibiting cell cycle progression, allowing cells to divide uncontrollably and eventually become cancerous.
• It is thought that the higher risk HPV infections, have the ability to inactivate tumor suppressor genes such as the p53 gene and the RB gene, thus allowing the infected cells to grow unchecked and accumulate successive mutations, eventually leading to cancer.